| Date | Location | Result | |
| 02/22/22 | Smith Court - Boston, Mass. | Suffolk 75, Endicott 73 | Box score |
| 02/19/22 | Beverly, Mass. (MacDonald Gymnasium) | Endicott 90, Suffolk 71 | Box score |
| 02/16/22 | Dudley, Mass. | Nichols 104, Endicott 96 (OT) | Box score |
| 02/14/22 | Beverly, Mass. (MacDonald Gymnasium) | Endicott 76, Wentworth 68 | Box score |
| 02/12/22 | Newport, R.I. (Rodgers Rec Center) | Salve Regina 72, Endicott 64 | Box score |
| 02/10/22 | Beverly, Mass. (MacDonald Gym) | Nichols 71, Endicott 68 | Box score |
| 02/08/22 | Beverly, Mass. (MacDonald Gym) | Endicott 82, Curry 68 | Box score |
| 02/05/22 | Bristol, R.I. (Campus Rec Center) | Roger Williams 80, Endicott 60 | Box score |
| 02/02/22 | Springfield, MA | Western New Eng. 98, Endicott 90 | Box score |
| 01/27/22 | Beverly, Mass. (MacDonald Gymnasium) | Western New England 87, Endicott 82 | Box score |
| 01/25/22 | Biddeford, Maine (Harold Alfond Forum) | Endicott 66, Univ. of New England 63 | Box score |
| 01/22/22 | Beverly, Mass. (MacDonald Gymnasium) | Endicott 61, Gordon 53 | Box score |
| 1/19/22 | Beverly, Mass. (MacDonald Gymnasium) | Endicott 92, Roger Williams 72 | Box score |
| 01/17/22 | Boston, Mass. (Tansey Gymnasium) | Endicott 63, Wentworth 62 | Box score |
| 01/15/22 | Smith Court - Boston, Mass. | Suffolk 86, Endicott 82 | Box score |
| 01/08/22 | Milton, MA | Endicott 95, Curry 63 | Box score |
| 12/9/21 | Beverly, Mass. | Endicott 78, Salem State 74 | Box score |
| 12/4/21 | Beverly, Mass. (MacDonald Gym) | Salve Regina 64, Endicott 62 | Box score |
| 12/1/21 | Kanas Court/Wenham, Mass. | Endicott 82, Gordon 55 | Box score |
| 11/28/21 | Middlebury, VT | Middlebury 86, Endicott 81 | Box score |
| 11/20/21 | Beverly, MA | Endicott 72, U New England 67 | Box score |
| 11/16/21 | Cambridge, Mass. | MIT 75, Endicott 72 | Box score |
| 11/13/21 | Boston, Mass. - Emmanuel College | Endicott 77, Framingham St. 58 | Box score |
| 11/12/21 | Boston, Mass. - Emmanuel College | Endicott 89, Bridgewater St. 71 | Box score |